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a alternata extract  (Greer Laboratories)

 
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    Greer Laboratories a alternata extract
    A Alternata Extract, supplied by Greer Laboratories, used in various techniques. Bioz Stars score: 86/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/a+alternata+extract/pmc13140411-144-30-33?v=Greer+Laboratories
    Average 86 stars, based on 1 article reviews
    a alternata extract - by Bioz Stars, 2026-08
    86/100 stars

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    a alternata extract  (Greer Laboratories)
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    CD4 + -specific PGI 2 signaling attenuates <t>Alternaria</t> -induced Th2 lung inflammation. (A) IP receptor expression (RT-PCR) in CD4 + T cells from CD4 Cre- IP flox (control) and CD4 Cre+ IP flox (IP-deficient) mice. (B) Experimental timeline: mice were intranasally sensitized/challenged daily with Alt on days 0 to 2 and 15 or 16, with mouse harvest on day 17. (C–E) IL-5, IL-13, and CCL11 levels in lung homogenates (ELISA). (F–J) BALF cellularity: total cells, eosinophils, lymphocytes, macrophages, and neutrophils. (K–L) PAS-stained mucus production (representative image and quantification). (K, M–N) Hematoxylin and eosin (H&E)–stained inflammation (representative image and scores for peribronchiolar/perivascular infiltration). Data represent 3 experiments (n = 5–18 mice/group). * P < 0.05 by 2-way analysis of variance.
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    CD4 + -specific PGI 2 signaling attenuates Alternaria -induced Th2 lung inflammation. (A) IP receptor expression (RT-PCR) in CD4 + T cells from CD4 Cre- IP flox (control) and CD4 Cre+ IP flox (IP-deficient) mice. (B) Experimental timeline: mice were intranasally sensitized/challenged daily with Alt on days 0 to 2 and 15 or 16, with mouse harvest on day 17. (C–E) IL-5, IL-13, and CCL11 levels in lung homogenates (ELISA). (F–J) BALF cellularity: total cells, eosinophils, lymphocytes, macrophages, and neutrophils. (K–L) PAS-stained mucus production (representative image and quantification). (K, M–N) Hematoxylin and eosin (H&E)–stained inflammation (representative image and scores for peribronchiolar/perivascular infiltration). Data represent 3 experiments (n = 5–18 mice/group). * P < 0.05 by 2-way analysis of variance.

    Journal: The Journal of Immunology Author Choice

    Article Title: PGI 2 signaling metabolically reprograms CD4 Th2 cells and represses allergic airway inflammation

    doi: 10.1093/jimmun/vkaf130

    Figure Lengend Snippet: CD4 + -specific PGI 2 signaling attenuates Alternaria -induced Th2 lung inflammation. (A) IP receptor expression (RT-PCR) in CD4 + T cells from CD4 Cre- IP flox (control) and CD4 Cre+ IP flox (IP-deficient) mice. (B) Experimental timeline: mice were intranasally sensitized/challenged daily with Alt on days 0 to 2 and 15 or 16, with mouse harvest on day 17. (C–E) IL-5, IL-13, and CCL11 levels in lung homogenates (ELISA). (F–J) BALF cellularity: total cells, eosinophils, lymphocytes, macrophages, and neutrophils. (K–L) PAS-stained mucus production (representative image and quantification). (K, M–N) Hematoxylin and eosin (H&E)–stained inflammation (representative image and scores for peribronchiolar/perivascular infiltration). Data represent 3 experiments (n = 5–18 mice/group). * P < 0.05 by 2-way analysis of variance.

    Article Snippet: CD4 Cre- IP flox and CD4 Cre+ IP flox mice were sensitized intranasally with Alternaria alternata extract (Alt) (Greer Laboratories; 2 μg in 40 μL PBS per mouse) or PBS as a control for 3 d. After a 13-d rest period, mice were challenged with Alt (0.125 μg in 40 μL PBS per mouse) for 2 consecutive days.

    Techniques: Expressing, Reverse Transcription Polymerase Chain Reaction, Control, Enzyme-linked Immunosorbent Assay, Staining